1.00 488. Aspartame (WHO Food Additives Series 15)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v15je03.htm
Summary: Incubation of Methyl 14C-labelled aspartame with fresh rat plasma resulted in demethylation of the aspartame (Anonymous, 1972a). Male rats (300 g) were dosed orally with 0.5 ml of an aqueous solution of phenylalanine 14C-aspartame (10 mg/ml). Plasma 14C

1.00 497. Aspartame (WHO Food Additives Series 16)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v16je03.htm
Summary: Aspartame was first evaluated by JECFA in 1975 (see Annex, Ref. 51). In 1980 JECFA evaluated additional toxicity animal studies and several human studies and an ADI of 0-40 mg/kg bw for aspertame and an ADI of 0-7.5 mg/kg bw for its breakdown, diketopipe

0.97 Methanol (EHC 196, 1997)

05-18-04, http://www.inchem.org/documents/ehc/ehc/ehc196.htm
Summary: The International Programme on Chemical Safety (IPCS) is a joint venture of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. Supporting activities include the development of epidemiologic

0.91 OCHRATOXIN A (JECFA 47, 2001)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v47je04.htm
Summary: Biliary excretion of ochratoxin A was increased and urinary excretion of ochratoxin A and ochratoxin alpha was decreased in mice pretreated with phenobarbital (Moroi et al. A dose-related inhibition of protein synthesis was found in mice given ochratoxin

0.87 JECFA Evaluations-ASPARTAME-

05-18-04, http://www.inchem.org/documents/jecfa/jeceval/jec_147.htm
Summary: Previous status: 1981, FNP 19-JECFA 25/23. R; COMPENDIUM/161 1980, TRS 653-JECFA 24/20, FNP 17-JECFA 24/10, FAS 15-JECFA 24/18. 0-40 (ADI FOR DIKETOPIPERAZINE-IMPURITY FOUND IN ASPARTAME: 0-7.5) FU. S 1977, TRS 617-JECFA 21/23. DECISION POSTPONED. S,T 1

0.87 JECFA Evaluations-ASPARTAME-ACESULFAME SALT-

05-18-04, http://www.inchem.org/documents/jecfa/jeceval/jec_148.htm
Summary: Summary of Evaluations Performed by theJoint FAO/WHO Expert Committee on Food Additives Chemical names: 6-METHYL-1,2,3-OXATHIAZINE-4(3H)-ONE-2,2-DIOXIDE SALT OF L-PHENYLALANYL-2-METHYL-L-alpha-ASPARTIC ACID Comments: Aspartame and acesulfame moieties are

0.85 638. Glutamic acid and its salts (WHO Food Additives Series 22)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v22je12.htm
Summary: The ADI did not apply to infants under 12 weeks of age and further work required if the use was to be extended to infant foods included the determination of oral non-adverse effect levels of glutamates in neonatal animals and age correlations between neon

0.82 495. Introduction (WHO Food Additives Series 16)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v16je01.htm
Summary: The International Programme on Chemical Safety (IPCS), established in 1980, is a joint venture of the United Nations Environment Programme (UNEP), the International Labour Organisation (ILO), and the World Health Organization (WHO). Any new information a

0.80 ANNEX 1

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v46je17.htm
Summary: e The Committee concluded that cochineal extract, carmines, and possibly carminic acid in foods and beverages may provoke allergic reactions in some individuals. g No conclusions could be drawn about the acceptability of the uses proposed in the draft Gen

0.80 844. Nitrite (WHO Food Additives Series 35)

05-18-04, http://www.inchem.org/documents/jecfa/jecmono/v35je13.htm
Summary: This ADI was based on a marginal reduction in body-weight gain at a dose level of 100 mg/kg bw/day in a long-term study in rats. Nitrite rapidly disappeared from a buffered solution at pH&lt5, simulating gastric conditions, and the rate of disappearance